Having Fun with 23andme - the joys and broader vision

Genetic identity products like the 23andme product I purchased recently have been wildly popular.  The US Food and Drug Administration (FDA) took the medical portion of the product off the market until concerns about how the info would be used could be addressed.  It’s so easy for someone who doesn’t have a deep background in genetics to misunderstand what a predisposition could refer to. 

As a larger issue, there is a real danger of employers in the US getting access to genetic information, because they WILL refuse to hire, and WILL find excuses to get rid of any person who might (big word there!) have a medical problem in the future – that their health insurance company would have to pay for.  The real villain in that scenario is insurance that is tied to an employer, not a basic right of citizenship, because it gives your employer a powerful motivation to get rid of you based on your potential for expensive health problems.  If your health is an issue for you and the community that pays for all its citizens, your employer is out of the loop.

But back to products that promise to give you insights into your genetic identity.  The 23andme product that I bought for myself and my husband included some basics from the nuclear DNA and from mitchondrial DNA with (for men only) some info from the Y chromosome.  To recap:  Your nuclear DNA comes from your mother and your father, and gets shuffled around in each generation.  Your mitochondrial DNA comes from the egg that started your journey to life, so it is entirely from your mother.  [Your dad’s sperm has nothing but nuclear DNA to make it as light and fast as possible.]  It doesn’t mix and match with every generation, but provides an unbroken, except by mutations, lineage from some very ancient woman.  Men’s Y-chromosomes also provide an unbroken lineage, except for mutations, from a very ancient man. 

Another aside: a group of Jewish South Africans who claimed biological descent as Cohens (a priestly family in ancient Palestine) were never believed because to all outward appearances they were just black South Africans.  But a Y-chromosome study proved them right; that DNA came from ancient Palestine and was similar to other Jewish Cohens who were still living in their ancestral home. 

I will admit that I paid the money ($180 for the two of us) for entertainment purposes, and that’s a good way to approach any consumer product.  We both could see the known outlines of our ancestry popping up in the numbers. 

What everyone except me misinterpreted and what I want to talk about is the small amounts of DNA in which I resemble folks in east and west Africa, Oceania and East Asia.  The immediate assumption is that I have a distant ancestor from those places.  I wouldn’t mind if I did, and it could be.  A more likely explanation is the mundane genetic fact that similarity doesn’t necessarily mean direct ancestry.  It most likely means that I have some very old DNA that hasn’t changed since all of us were encapsulated in 2000 individuals living in East Africa, 60,000 years ago.  A bit of it went west to west Africa, a bit of it took off into the Middle East and from there travelled to East Asia and then to Oceania, and the rest became the Neolithic farmers who moved into Europe, killed off the hunter/gatherers and took their land.  Horticulture and agriculture allowed my ancestors to feed more kids and breed more fighters, it was that simple.   My mitochondrial DNA supports that narrative.  There are a lot of fascinating details, that I am keeping appropriately private.  I’m less Neandertal than the average European. 

And I am re-assessing the “purely entertainment” motive.  Right after I received my genetic info, I researched more about the various identified groups and genes and found myself profoundly moved.  One of my course offerings is a fascinating journey to consult with one’s biological forebears.  It has been inspiring and profoundly healing for many people.  Looking at the geographical distribution of those maternal haplogroups led me to take the journey myself, psychically touching those women who lived so long ago.  [Email me for more information on the course.]

We can get so wound up in our daily to-do lists that we forget to, as my course encourages, visit with our very distant ancestors, to put a larger perspective on our lives.  All 10,000 generations of them changed their culture and their world in all the small ways that a person’s life does.  

We have the opportunity and the privilege to be beacons of love, comfort and inspiration in our own time.  This little glimpse into the past reminded me of my duty to do my very best with the life that all these fascinating ancestors have given me.